A new algorithm based on artificial neural network is presented as a software compensation to improve the non-linearity of pressure sensor and the output error characteristics caused by the variation of temperatures.It consists of the regulation for four weights,which stand for the coefficients of one and two powers of output signals and temperatures,respectively.An optimum output formula is obtained after a lot of iterations.This formula satisfies both sample values and other values among them and can check the correctness of the final iteration results of this artificial neural network computing.