A Study on Structural Flexibility in Escherichia Coli Genome

CAI Lu; SUN Zhi-rong

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A Study on Structural Flexibility in Escherichia Coli Genome

更新时间：2025-07-16

- A Study on Structural Flexibility in Escherichia Coli Genome
- Acta Electronica Sinica Vol. 29, Issue S1, Pages: 1753-1755(2001)
- 作者机构：
  
  1. 包头钢铁学院生物与化学工程系,内蒙古,包头,014010
  2. 清华大学生命科学和技术系,北京,100084
- 作者简介：
- 基金信息：
- DOI：
  CLC： Q617
- Published：2001
- 稿件说明：
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CAI Lu, SUN Zhi-rong. A Study on Structural Flexibility in Escherichia Coli Genome[J]. Acta Electronica Sinica, 2001, 29(S1): 1753-1755.
DOI：

CAI Lu, SUN Zhi-rong. A Study on Structural Flexibility in Escherichia Coli Genome[J]. Acta Electronica Sinica, 2001, 29(S1): 1753-1755. DOI：

摘要

基于四核苷酸参数提出一个统计力学模型用于分析大肠杆菌基因组柔性.结果表明:大肠杆菌基因组复制终止区柔性明显小于其他区域 ;柔性和G+C含量之间具有极强的关联;编码区的平均柔性明显大于非编码区的平均柔性.对大肠杆菌基因组中三类类型启动子序列的结构柔性特征也作了分析.

Abstract

Based on tetranucleotide parameters

a statistical mechanical model was suggested to analyze the flexibility of the Escherichia coli genome.The terminus region of replication displayed a low level of flexibility.A strong correlation between G+C content and flexibility can be seen.Average flexibilities in coding regions were found to be significantly larger than those in non-coding regions.The flexible characteristics in three class sigma promoter sequences in the Escherichia coli genome were also analyzed.

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