Based on the different statistical characteristics of Doppler ultrasound blood flow signals and wall clutter signals

the non-uniform sampling and cubic spline reconstruction are applied to the mixed signals to obtain the wall signals

and consequently blood signals.This novel method

together with the traditional high-pass filtering method

is applied to both computer simulated Doppler ultrasound signals and collected human carotid Doppler ultrasound signals.The comparison experiments indicate that the proposed method can remove wall clutter signals with preservation of low frequency blood components

thus is suitable for the separation of the wall and blood signals in Doppler ultrasound systems.