An integrated circuit pressure transducer consisting of a full bridge of piezo-resistors with a novel design and an amplifier with temperature compensation is described. The configuration and dimension of the （100） rectangular Si diaphragm as well as the locations and the dimensions of the resistors are optimized through careful computation. The temperature coefficient of the whole circuit is analysed and minimized. The design has been implemented by conventional bipolar IC technology and anisotropic chemical etching. The transducers fabricated show a sensitivity of about 1000 μV/mmHg and have been used for physiological pressure measurement in clinical applications.