MEDAguard: A Logic Encryption Scheme for Micro-Electrode-Dot-Array Biochips IP Protection

LIU Ling-qing; DONG Chen; LIU Xi-meng; LIU Huang-da; LIAN Si-huang; CHEN Xiao

doi:10.12263/DZXB.20210556

您当前的位置：

首页 >

文章列表页 >

MEDAguard: A Logic Encryption Scheme for Micro-Electrode-Dot-Array Biochips IP Protection

PAPERS | 更新时间：2025-12-08

- MEDAguard: A Logic Encryption Scheme for Micro-Electrode-Dot-Array Biochips IP Protection
- ACTA ELECTRONICA SINICA Vol. 50, Issue 2, Pages: 440-445(2022)
- 作者机构：
  
  1.福州大学计算机与大数据学院, 福建福州 350116
  2.网络系统信息安全福建省高校重点实验室, 福建福州 350116
  3.福建省网络计算与智能信息处理重点实验室, 福建福州 350116
- 作者简介：
- 基金信息：
- DOI：10.12263/DZXB.20210556
  CLC： TP309
- Received：30 April 2021，
  
  Revised：2021-09-14，
  
  Published：25 February 2022
- 稿件说明：
移动端阅览
刘灵清,董晨,刘西蒙等.MEDAguard：基于逻辑加密的微电极点阵生物芯片知识产权保护方案[J].电子学报,2022,50(02):440-445.

LIU Ling-qing,DONG Chen,LIU Xi-meng,et al.MEDAguard: A Logic Encryption Scheme for Micro-Electrode-Dot-Array Biochips IP Protection[J].ACTA ELECTRONICA SINICA,2022,50(02):440-445.
刘灵清,董晨,刘西蒙等.MEDAguard：基于逻辑加密的微电极点阵生物芯片知识产权保护方案[J].电子学报,2022,50(02):440-445. DOI： 10.12263/DZXB.20210556.

LIU Ling-qing,DONG Chen,LIU Xi-meng,et al.MEDAguard: A Logic Encryption Scheme for Micro-Electrode-Dot-Array Biochips IP Protection[J].ACTA ELECTRONICA SINICA,2022,50(02):440-445. DOI： 10.12263/DZXB.20210556.

摘要

在微电极点阵（Micro-Electrode-Dot-Array，MEDA）生物芯片外包生产的过程中，未受保护的芯片设计知识产权容易遭受盗窃或过度生产攻击.本文提出一种基于逻辑加密的微电极点阵生物芯片的知识产权保护方案，称为MEDAguard，该方案使用生化协议中的废液滴和输入液滴构成逻辑加密模块，实现对生化协议的锁定，从而保护生化协议在外包生产过程中不被窃取.针对破解密钥最常用的暴力攻击法，提出一种安全性评价指标，用于评估生成的生化试剂是否符合浓度标准.采用多组仿真实验模拟攻击者对MEDAguard实施暴力攻击，实验结果表明MEDAguard能够有效地抵抗暴力攻击.

Abstract

In the process of outsourcing the production of micro-electrode-dot-array(MEDA) biochips

the unprotected IP(intellectual property) of the chip design is vulnerable to theft or overproduction attacks. This paper proposes a logic encryption-based IP protection scheme for micro-electrode-dot-array biochips

called MEDAguard

which uses waste droplets and input droplets from bioassay to form logic encryption modules to lock the bioassay

thereby protecting it from theft during the outsourcing process. In addition

a security evaluation metric is proposed to assess whether the generated biochemical reagents meet the concentration criteria for compliance against the brute-force attack method most commonly used to break the key. Finally

several simulations are used to simulate a brute-force attack on MEDAguard

and the results show that MEDAguard can effectively resist brute-force attacks.

关键词

Keywords

references

DONG C , LIU L , LIU H , et al . A survey of DMFBs security: State-of-the-art attack and defense [C]// Proceedings of International Symposium on Quality Electronic Design . Santa Clara, USA : IEEE , 2020 : 14 ‑ 20 .

LAI K Y T , YANG Y T , LEE C Y . An intelligent digital microfluidic processor for biomedical detection [J]. Journal of Signal Processing Systems , 2015 , 78 ( 1 ): 85 ‑ 93 .

SHAYAN M , BHATTACHARJEE S , LIANG T C , et al . Shadow attacks on MEDA biochips [C]// IEEE/ACM International Conference on Computer-Aided Design . San Diego, USA : IEEE , 2018 : 1 ‑ 8 .

KESZOCZE O , LI Z , GRIMMER A , et al . Exact routing for micro-electrode-dot-array digital microfluidic biochips [C]// Proceedings of the Asia and South Pacific Design Automation Conference . Chiba, Japan : IEEE , 2017 : 708 ‑ 713 .

ZHONG Z , LI Z , CHAKRABARTY K . Adaptive error recovery in MEDA biochips based on droplet-aliquot operations and predictive analysis [C]// IEEE/ACM International Conference on Computer‑Aided Design , Digest of Technical Papers. Irvine , USA : IEEE , 2017 : 615 ‑ 622 .

LIANG T C , CHAKRABARTY K , KARRI R . Programmable daisychaining of microelectrodes to secure bioassay IP in MEDA biochips [J]. IEEE Transactions on Very Large Scale Integration Systems , 2020 , 28 ( 5 ): 1269 ‑ 282 .

BHATTACHARJEE S , TANG J , PODDAR S , et al . Bio-chemical assay locking to thwart bio-IP theft [J]. ACM Transactions on Design Automation of Electronic Systems , 2019 , 25 ( 1 ): 1 ‑ 20 .

MA J , LEE S M Y , YI C , et al . Controllable synthesis of functional nanoparticles by microfluidic platforms for biomedical applications-a review [J]. Lab on a Chip , 2017 , 17 ( 2 ): 209 ‑ 226 .

LI C W , YU G , JIANG J , et al . A microfluidic linear node array for the study of protein-ligand interactions [J]. Lab on a Chip , 2014 , 14 ( 20 ): 3993 ‑ 3999 .

HE J L , CHEN A Te , LEE J H , et al . Digital microfluidics for manipulation and analysis of a single cell [J]. International Journal of Molecular Sciences , 2015 , 16 ( 9 ): 2 2319‑ 22332 .

LIANG T C , CHAN Y S , HO T Y , et al . Sample preparation for multiple-reactant bioassays on micro-electrode-dot-array biochips [C]// Proceedings of the Asia and South Pacific Design Automation Conference . New York, USA : ACM , 2019 : 468 ‑ 473 .

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

A Multivariate Encryption for Chip Design Protection and Its Circuit Architecture

Related Author

Ling-qing LIU

Chen DONG

Xi-meng LIU

Huang-da LIU

Si-huang LIAN

Xiao CHEN

ZHAO Xian-feng

LI Ning

Related Institution

College of Computer and Data Science， Fuzhou University

Key Lab of Information Security of Network Systems， Fuzhou University

Fujian Key Laboratory of Network Computing and Intelligent Information Processing， Fuzhou University

State Key Laboratory of Information Security,Institute of Software,Chinese Academy of Sciences

Department of Electronic Engineering and Information Science,University of Science and Technology of China

⁰