Research on Calibration Method of Flexible Blood Pressure Sensor Based on Photoplethysmography

SHI Wei; DONG Lin-xi; WENG Bin-hui; CHENG Jia-gen; YANG Wei-huang; LIU Chao-ran

doi:10.12263/DZXB.20230191

您当前的位置：

首页 >

文章列表页 >

Research on Calibration Method of Flexible Blood Pressure Sensor Based on Photoplethysmography

PAPERS | 更新时间：2025-12-08

- Research on Calibration Method of Flexible Blood Pressure Sensor Based on Photoplethysmography
- ACTA ELECTRONICA SINICA Vol. 52, Issue 8, Pages: 2648-2658(2024)
- 作者机构：
  
  1.杭州电子科技大学电子信息学院，浙江杭州 310018
  2.智能微传感器与微系统教育部工程研究中心，浙江杭州 310018
- 作者简介：
- 基金信息：
  
  National Key Research and Development Program of China(2022YFB3204802);National Natural Science Foundation of China(U1909221;61871167);Zhejiang Provincial Talent Project(2021R52009)
- DOI：10.12263/DZXB.20230191
  CLC： TN29;
- Received：03 March 2023，
  
  Revised：2023-09-15，
  
  Published：25 August 2024
- 稿件说明：
移动端阅览
时未, 董林玺, 翁斌辉, 等. 基于光电容积脉搏波描记法的柔性血压传感器标定方法研究[J]. 电子学报, 2024, 52(08): 2648-2658.

SHI Wei, DONG Lin-xi, WENG Bin-hui, et al. Research on Calibration Method of Flexible Blood Pressure Sensor Based on Photoplethysmography[J]. Acta Electronica Sinica, 2024, 52(08): 2648-2658.
时未, 董林玺, 翁斌辉, 等. 基于光电容积脉搏波描记法的柔性血压传感器标定方法研究[J]. 电子学报, 2024, 52(08): 2648-2658. DOI：10.12263/DZXB.20230191

SHI Wei, DONG Lin-xi, WENG Bin-hui, et al. Research on Calibration Method of Flexible Blood Pressure Sensor Based on Photoplethysmography[J]. Acta Electronica Sinica, 2024, 52(08): 2648-2658. DOI：10.12263/DZXB.20230191

摘要

基于光电容积脉搏波描记法（Photo Plethysmo Graphy，PPG）的柔性传感器可进行心率（Heart Rate，HR）和血压（Blood Pressure，BP）检测，但是对其检测结果的标定报道甚少.据此，本文提出一种基于模拟血液循环的反射式PPG心率检测和血压标定系统.以蠕动泵来产生脉动流，通过调节其转速的大小来控制模拟血液输送的频率和压力，从而引起弹性乳胶管内模拟血液体积的变化，而改变反射光的信号周期与强度，贴近于人体脉搏测量过程的实际场景.该系统心率检测误差均值为0.277 78，95%一致性界限为（-2.595 62，3.151 17），所测收缩压（Systolic Blood Pressure，SBP）和舒张压（Diastolic Blood Pressure，DBP）的拟合优度分别为0.971 85和0.981 11.经标定后的柔性PPG传感器对4名志愿者检测的SBP和DBP的平均偏差（Mean Deviation，MD）±标准差（Standard Deviation，SD）均值分别为（1.21±2.16） mmHg和（0.76±2.02） mmHg，均符合且远小于美国医疗仪器促进协会（Association for the Advancement of Medical Instrumentation，AAMI）所制定的衡量血压计精度的标准指标（5±8） mmHg.结果表明，该系统能够准确高效地标定柔性PPG传感器，为实现便携式可穿戴设备的精准血压检测提供标定基础.

Abstract

The flexible sensor based on photo plethysmo graphy (PPG) can detect heart rate (HR) and blood pressure (BP)

but the calibration of their detection results is rarely reported. Therefore

this paper proposes a reflective PPG heart rate detection and blood pressure calibration system based on simulated blood circulation.The peristaltic pump is used to generate pulsating flow

and the frequency and pressure of simulated blood delivery are controlled by adjusting its rotational speed

thus causing the change of the volume of simulated blood in the elastic latex tube and changing the signal period and intensity of reflected light

which is closer to match the actual scenario of human pulse measurement process.The mean value of heart rate detection error of the system is 0.277 78

and the 95% consistency limit is (-2.595 62

3.151 17). The goodness of fit of measured systolic blood pressure (SBP) and diastolic blood pressure (DBP) are 0.971 85 and 0.981 11

respectively. The mean value of mean deviation (MD) ± standard deviation (SD) of SBP and DBP detected by the calibrated flexible PPG sensor on four volunteers is (1.21±2.16) mmHg and (0.76±2.02) mmHg

respectively

which are in line with and far less than the standard index of 5±8 mmHg for measuring the accuracy of blood pressure monitors set by the association for the advancement of medical instrumentation (AAMI). The results show that this system can calibrate the flexible PPG sensor accurately and efficiently

which provides the calibration basis for the accurate blood pressure detection of portable wearable devices.

关键词

Keywords

references

SCHUTTE A E , KOLLIAS A , STERGIOU G S . Blood pressure and its variability: Classic and novel measurement techniques [J ] . Nature Reviews Cardiology , 2022 , 19 : 643 - 654 .

CHANDRASEKHAR A , NATARAJAN K , YAVARIMANESH M , et al . An iPhone application for blood pressure monitoring via the oscillometric finger pressing method [J ] . Scientific Reports , 2018 , 8 : 13136 .

SEMPIONATTO J R , LIN M Y , YIN L , et al . An epidermal patch for the simultaneous monitoring of haemodynamic and metabolic biomarkers [J ] . Nature Biomedical Engineering , 2021 , 5 : 737 - 748 .

TANAKA S , NOGAWA M , YAMAKOSHI T , et al . Accuracy assessment of a noninvasive device for monitoring beat-by-beat blood pressure in the radial artery using the volume-compensation method [J ] . IEEE Transactions on Biomedical Engineering , 2007 , 54 ( 10 ): 1892 - 1895 .

LI H C , MA Y J , LIANG Z W , et al . Wearable skin-like optoelectronic systems with suppression of motion artifacts for cuff-less continuous blood pressure monitor [J ] . National Science Review , 2020 , 7 ( 5 ): 849 - 862 .

CHEN B M , SONG T Y , GUO T , et al . A simplified computer model of cardiovascular system with an arm branch [J ] . Bio-Medical Materials and Engineering , 2014 , 24 ( 6 ): 2555 - 2561 .

胡海洋 . 基于示波法的无创血压模拟系统的研制 [D ] . 合肥 : 安徽医科大学 , 2020 .

HU H Y . Development of Oscillometric Non-Invasive Blood Pressure Simulation System [D ] . Hefei : Anhui Medical University , 2020 . (in Chinese)

DOHI T , URATA H , FUKAHORI S , et al . A continuous and wearable blood pressure measurement device with MEMS 3-axis force sensor array [C ] // 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII) . Piscataway : IEEE , 2019 : 2182 - 2184 .

李杜娟 , 陈慧旖 , 刘超然 , 等 . 基于微纳加工技术的生物传感器研究进展 [J ] . 电子学报 , 2021 , 49 ( 6 ): 1228 - 1236 .

LI D J , CHEN H Y , LIU C R , et al . A review on MEMS/NEMS-based biosensor [J ] . Acta Electronica Sinica , 2021 , 49 ( 6 ): 1228 - 1236 . (in Chinese)

SHI P , YU H L . Principles of photoplethysmography and its applications in physiological measurements [J ] . Journal of Biomedical Engineering , 2013 , 30 ( 4 ): 899 - 904 .

罗美红 . 体外血流动力学特性测试装置研制 [D ] . 南昌 : 南昌大学 , 2016 .

LUO M H . Hemodynamic Characteristics Device Test Development in Vitro [D ] . Nanchang : Nanchang University , 2016 . (in Chinese)

KORTEWEG D J . Ueber die Fortpflanzungsgeschwindigkeit des Schalles in elastischen Röhren [J ] . Annalen Der Physik , 1878 , 241 ( 12 ): 525 - 542 .

HUGHES D J , BABBS C F , GEDDES L A , et al . Measurements of Young’s modulus of elasticity of the canine aorta with ultrasound [J ] . Ultrasonic Imaging , 1979 , 1 ( 4 ): 356 - 367 .

GUO C Y , CHANG C C , WANG K J , et al . Assessment of a calibration-free method of cuffless blood pressure measurement: A pilot study [J ] . IEEE Journal of Translational Engineering in Health and Medicine , 2022 , 11 : 318 - 329 .

YU C , LIN Z , YU Y . Principles and design of infrared gas concentration detection device [C ] // 2010 3rd International Conference on Biomedical Engineering and Informatics . Piscataway : IEEE , 2010 : 1556 - 1559 .

OSANAI H . Plethysmographic Acceleration Pulse Wave Meter : US4432374 [P ] . 1984-02-21 .

LIU M Y , PO L M , FU H . Cuffless blood pressure estimation based on photoplethysmography signal and its second derivative [J ] . International Journal of Computer Theory and Engineering , 2017 , 9 ( 3 ): 202 - 206 .

LIU W J , CHENG J G , WU Z T , et al . A wearable and flexible photoplethysmogram sensor patch for cuffless blood pressure estimation with high accuracy [J ] . IEEE Sensors Journal , 2022 , 22 ( 20 ): 19818 - 19825 .

KIM I , BHAGAT Y A . Towards development of a mobile RF Doppler sensor for continuous heart rate variability and blood pressure monitoring [C ] // 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) . Piscataway : IEEE , 2016 : 3390 - 3393 .

蒋潘婷 . 基于脉搏波传导时间的可穿戴血压检测芯片的算法研究与电路设计 [D ] . 武汉 : 华中科技大学 , 2019 .

JIANG P T . Algorithm Research and Circuit Design of Wearable Blood Pressure Detection Chip Based on Pulse Transit Time [D ] . Wuhan : Huazhong University of Science and Technology , 2019 . (in Chinese)

GUO T T , ZHANG T P , LIM E , et al . A review of wavelet analysis and its applications: Challenges and opportunities [J ] . IEEE Access , 2022 , 10 : 58869 - 58903 .

HAN M , LIU Y H , XI J H , et al . Noise smoothing for nonlinear time series using wavelet soft threshold [J ] . IEEE Signal Processing Letters , 2007 , 14 ( 1 ): 62 - 65 .

ATTARPOUR A , MAHNAM A , AMINITABAR A , et al . Cuff-less continuous measurement of blood pressure using wrist and fingertip photo-plethysmograms: Evaluation and feature analysis [J ] . Biomedical Signal Processing and Control , 2019 , 49 : 212 - 220 .

DOĞAN N Ö . Bland-Altman analysis: A paradigm to understand correlation and agreement [J ] . Turkish Journal of Emergency Medicine , 2018 , 18 ( 4 ): 139 - 141 .

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

No data

Related Author

No data

Related Institution

No data

⁰