The response of SPR sensor includes two components:specific response and non-specific response.The former is due to the capture of analyte molecules by target molecules immobilized on the sensor surface

and the latter is due to the adsorption of non-target molecules to sensor surface and temperature fluctuations or sample variations of composition and concentration.The existence of non-specific response reduces the precision of SPR sensors.In this paper we provide a kind of multi-channel SPR imaging sensor structure to improve the accuracy of SPR sensors.It can discriminate between the specific response and the non-specific response by comparison of different channels

and realize the real-time detection of the biomolecular interactions.This method is demonstrated effective on specific detection by testing for DNA.