The human immune system has many features for inspirations to information security.We design a framework model using an analogy of human immune mechanism.This model can be used to provide the protection for the safety of important information.The suggested framework consists of two parallel information transmit networks:conventional transmit network(CTN) and immune lympho id transmit network(ILTN).conventional transmit network provides the end to end services and transmits important information from one end point to another.Immune lymph transmit network provides authentication and control services that monitor and manage the activities of conventional transmit network.We also discuss a solution to the security of the mobile agent.This paper also accomplished corresponding experiments.The results of the experiment showed that the use of this model is very efficient for the problem of discrimination of the self and non-self.