A new method of WLS (weighted least square) estimation-based time-voltage QRS area extraction by dual-lead has been put forward in this paper.Based on the point inside the QRS complexes

the WLS estimations and linear measurements of linear segments from this point have been calculated backward and forward.Based on these parameters

a basic linear segment has been checked out.On the basis of this basic linear segment

the onset and offset of the QRS complex are determined by the hypothesis testing.This method applied to another lead and the final onset and offset have been determined.Therefore the time-voltage QRS area has been extracted.The method has been successfully applied to all 105 records of QT database from MIT-BIH database;it has reached the precision of 97.5% on the 3623 QRSs marked by one group of cardiologists and 98.0% on the 404 QRSs marked by another group of cardiologists.It has made a foundation for real-time and automatic computer- diagnosis of ECG without man-machine alternation.