基于光电容积脉搏波描记法的柔性血压传感器标定方法研究

时未; 董林玺; 翁斌辉; 程家根; 杨伟煌; 刘超然

doi:10.12263/DZXB.20230191

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基于光电容积脉搏波描记法的柔性血压传感器标定方法研究

学术论文 | 更新时间：2025-12-08

- 基于光电容积脉搏波描记法的柔性血压传感器标定方法研究
- Research on Calibration Method of Flexible Blood Pressure Sensor Based on Photoplethysmography
- 电子学报 2024年52卷第8期页码：2648-2658
- 作者机构：
  
  1.杭州电子科技大学电子信息学院，浙江杭州 310018
  2.智能微传感器与微系统教育部工程研究中心，浙江杭州 310018
- 作者简介：
  
  [ "时未女，1998年5月出生于江苏省盐城市.现为杭州电子科技大学电子信息学院电子信息专业硕士研究生.主要研究方向为集成电路、柔性可穿戴传感器.E-mail: shiwei@hdu.edu.cn" ]
  [ "董林玺男，1976年1月出生于山东省寿光市.现为杭州电子科技大学电子信息学院智能微传感器与微系统教育部工程研究中心教授，博士生导师.2004年获浙江大学微电子学与固体电子学专业博士学位.2015年至2016年，美国加州大学伯克利传感器和执行器中心访问教授.主要研究方向为工业物联网，传感器外围处理IC设计，MEMS传感器、谐振器及其微结构的设计、建模和制造.E-mail: donglinxi@hdu.edu.cn" ]
  [ "翁斌辉男，1998年3月出生于浙江省宁波市.2023年获杭州电子科技大学电子信息学院电子信息专业硕士学位.主要研究方向为集成电路、柔性可穿戴传感器.E-mail: wengbinhui980325@163.com" ]
  [ "程家根男，1996年3月出生于江西省鄱阳县.2023年获杭州电子科技大学电子信息学院电子信息专业硕士学位.目前在杭州电子科技大学攻读博士学位.主要研究方向为集成电路、柔性可穿戴电子器件和MEMS传感器.E-mail: cjg19960325@163.com" ]
  [ "杨伟煌男，1983年6月出生于福建省泉州市.现为杭州电子科技大学电子信息学院副教授，硕士研究生导师.2013年获厦门大学物理系凝聚态物理学博士学位，2016年新加坡南洋理工大学博士后出站.主要研究方向为二维材料的理论模拟、生长和特性、基于二维材料的光电器件和柔性微/纳米传感器的制备.E-mail: yangwh@hdu.edu.cn" ]
  [ "刘超然男，1987年9月出生于河南省周口市.现为杭州电子科技大学电子信息学院副教授，硕士研究生导师.佐治亚理工学院访问学者.主要研究方向为MEMS及新型自供电传感器、环境能量采集、柔性电子器件.E-mail: lincr@hdu.edu.cn" ]
- 基金信息：
  
  国家重点研发计划(2022YFB3204802);国家自然科学基金(U1909221;61871167);浙江省人才项目(2021R52009)
- DOI：10.12263/DZXB.20230191
  中图分类号： TN29;
- 收稿：2023-03-03，
  
  修回：2023-09-15，
  
  纸质出版：2024-08-25
- 稿件说明：
移动端阅览
时未, 董林玺, 翁斌辉, 等. 基于光电容积脉搏波描记法的柔性血压传感器标定方法研究[J]. 电子学报, 2024, 52(08): 2648-2658.

SHI Wei, DONG Lin-xi, WENG Bin-hui, et al. Research on Calibration Method of Flexible Blood Pressure Sensor Based on Photoplethysmography[J]. Acta Electronica Sinica, 2024, 52(08): 2648-2658.
时未, 董林玺, 翁斌辉, 等. 基于光电容积脉搏波描记法的柔性血压传感器标定方法研究[J]. 电子学报, 2024, 52(08): 2648-2658. DOI：10.12263/DZXB.20230191

SHI Wei, DONG Lin-xi, WENG Bin-hui, et al. Research on Calibration Method of Flexible Blood Pressure Sensor Based on Photoplethysmography[J]. Acta Electronica Sinica, 2024, 52(08): 2648-2658. DOI：10.12263/DZXB.20230191

摘要

基于光电容积脉搏波描记法（Photo Plethysmo Graphy，PPG）的柔性传感器可进行心率（Heart Rate，HR）和血压（Blood Pressure，BP）检测，但是对其检测结果的标定报道甚少.据此，本文提出一种基于模拟血液循环的反射式PPG心率检测和血压标定系统.以蠕动泵来产生脉动流，通过调节其转速的大小来控制模拟血液输送的频率和压力，从而引起弹性乳胶管内模拟血液体积的变化，而改变反射光的信号周期与强度，贴近于人体脉搏测量过程的实际场景.该系统心率检测误差均值为0.277 78，95%一致性界限为（-2.595 62，3.151 17），所测收缩压（Systolic Blood Pressure，SBP）和舒张压（Diastolic Blood Pressure，DBP）的拟合优度分别为0.971 85和0.981 11.经标定后的柔性PPG传感器对4名志愿者检测的SBP和DBP的平均偏差（Mean Deviation，MD）±标准差（Standard Deviation，SD）均值分别为（1.21±2.16） mmHg和（0.76±2.02） mmHg，均符合且远小于美国医疗仪器促进协会（Association for the Advancement of Medical Instrumentation，AAMI）所制定的衡量血压计精度的标准指标（5±8） mmHg.结果表明，该系统能够准确高效地标定柔性PPG传感器，为实现便携式可穿戴设备的精准血压检测提供标定基础.

Abstract

The flexible sensor based on photo plethysmo graphy (PPG) can detect heart rate (HR) and blood pressure (BP)

but the calibration of their detection results is rarely reported. Therefore

this paper proposes a reflective PPG heart rate detection and blood pressure calibration system based on simulated blood circulation.The peristaltic pump is used to generate pulsating flow

and the frequency and pressure of simulated blood delivery are controlled by adjusting its rotational speed

thus causing the change of the volume of simulated blood in the elastic latex tube and changing the signal period and intensity of reflected light

which is closer to match the actual scenario of human pulse measurement process.The mean value of heart rate detection error of the system is 0.277 78

and the 95% consistency limit is (-2.595 62

3.151 17). The goodness of fit of measured systolic blood pressure (SBP) and diastolic blood pressure (DBP) are 0.971 85 and 0.981 11

respectively. The mean value of mean deviation (MD) ± standard deviation (SD) of SBP and DBP detected by the calibrated flexible PPG sensor on four volunteers is (1.21±2.16) mmHg and (0.76±2.02) mmHg

respectively

which are in line with and far less than the standard index of 5±8 mmHg for measuring the accuracy of blood pressure monitors set by the association for the advancement of medical instrumentation (AAMI). The results show that this system can calibrate the flexible PPG sensor accurately and efficiently

which provides the calibration basis for the accurate blood pressure detection of portable wearable devices.

关键词

Keywords

references

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