Continuous loop averaging deconvolution (CLAD) is a newly developed method to recover the transient auditory evoked potential (AEP) from responses evoked by high stimulus rate sequences.This method brings forward a challenge in the generation of an appropriate stimulus sequence which will affect the deconvolution performance.We proposed a variant of differential evolution (DE) algorithm

namely solution-space contraction differential evolution (scDE) algorithm to optimize the sequence associated with an objective function defined in terms of the jitter ratio (JR) and the constraint condition in frequency domain.A dynamic scaling factor F in the mutation process was formulated to guarantee the gradual reduction of the searching-space.The scDE algorithm can be efficient in generating required sequences under various conditions with lower JR.This study is thus significant in promoting the application of CLAD method in basic and clinical research.