MEDAguard：基于逻辑加密的微电极点阵生物芯片知识产权保护方案

doi:10.12263/DZXB.20210556

电子学报 ›› 2022, Vol. 50 ›› Issue (2): 440-445.DOI: 10.12263/DZXB.20210556

MEDAguard：基于逻辑加密的微电极点阵生物芯片知识产权保护方案

刘灵清¹, 董晨¹^,³(), 刘西蒙¹^,²(), 柳煌达¹(), 连思璜¹(), 陈潇¹()

^1.福州大学计算机与大数据学院, 福建福州 350116
^2.网络系统信息安全福建省高校重点实验室, 福建福州 350116
^3.福建省网络计算与智能信息处理重点实验室, 福建福州 350116

收稿日期:2021-04-30 修回日期:2021-09-14 出版日期:2022-02-25
- 通讯作者:
- 董晨
- 作者简介:
- 刘灵清　男，1997年生于福建福州.现为福州大学计算机与大数据学院硕士研究生.主要研究方向为生物芯片安全.E-mail: liulqing07@foxmail.com
  董晨（通讯作者）女，1979年生于陕西西安.现为福州大学讲师、硕士生导师.主要研究方向为集成电路、生物芯片、人工智能芯片安全设计、人工智能、大数据等.E-mail: dongchen@fzu.edu.cn
  刘西蒙　男，1988年生于陕西西安.现为福州大学教授、博士生导师.主要研究方向为隐私计算、密文数据挖掘、大数据隐私保护、可搜索加密等.E-mail: snbnix@gmail.com
  柳煌达　男，1997年生于福建泉州.现为福州大学计算机与大数据学院硕士研究生.主要研究方向为生物芯片安全、人工智能.E-mail: hdaliu@foxmail.com
  连思璜　女，1996年生于福建泉州.现为福州大学计算机与大数据学院硕士研究生.主要研究方向为生物芯片安全.E-mail: sihlian@foxmail.com
  陈潇　女，1996年生于福建福州.现为福州大学计算机与大数据学院硕士研究生.主要研究方向为生物芯片安全.E-mail: chenx2653@foxmail.com
- 基金资助:
- 国家自然科学基金 (62072109); 福建省自然科学基金 (2020J01500)

MEDAguard: A Logic Encryption Scheme for Micro-Electrode-Dot-Array Biochips IP Protection

LIU Ling-qing¹, DONG Chen¹^,³(), LIU Xi-meng¹^,²(), LIU Huang-da¹(), LIAN Si-huang¹(), CHEN Xiao¹()

^1.College of Computer and Data Science, Fuzhou University, Fuzhou, Fujian 350116, China
^2.Key Laboratory of Information Security of Network Systems, Fuzhou University, Fuzhou, Fujian 350116, China
^3.Fujian Key Laboratory of Network Computing and Intelligent Information Processing, Fuzhou University, Fuzhou, Fujian 350116, China

Received:2021-04-30 Revised:2021-09-14 Online:2022-02-25 Published:2022-02-25
- Corresponding author:
- DONG Chen
- Supported by:
- National Natural Science Foundation of China (62072109); Natural Science Foundation of Fujian Province, China (2020J01500)

摘要/Abstract

摘要：

在微电极点阵（Micro-Electrode-Dot-Array，MEDA）生物芯片外包生产的过程中，未受保护的芯片设计知识产权容易遭受盗窃或过度生产攻击.本文提出一种基于逻辑加密的微电极点阵生物芯片的知识产权保护方案，称为MEDAguard，该方案使用生化协议中的废液滴和输入液滴构成逻辑加密模块，实现对生化协议的锁定，从而保护生化协议在外包生产过程中不被窃取.针对破解密钥最常用的暴力攻击法，提出一种安全性评价指标，用于评估生成的生化试剂是否符合浓度标准.采用多组仿真实验模拟攻击者对MEDAguard实施暴力攻击，实验结果表明MEDAguard能够有效地抵抗暴力攻击.

关键词: 微电极点阵, 生物芯片, 逻辑加密, 知识产权保护, 外包生产

Abstract:

In the process of outsourcing the production of micro-electrode-dot-array(MEDA) biochips, the unprotected IP(intellectual property) of the chip design is vulnerable to theft or overproduction attacks. This paper proposes a logic encryption-based IP protection scheme for micro-electrode-dot-array biochips, called MEDAguard, which uses waste droplets and input droplets from bioassay to form logic encryption modules to lock the bioassay, thereby protecting it from theft during the outsourcing process. In addition, a security evaluation metric is proposed to assess whether the generated biochemical reagents meet the concentration criteria for compliance against the brute-force attack method most commonly used to break the key. Finally, several simulations are used to simulate a brute-force attack on MEDAguard, and the results show that MEDAguard can effectively resist brute-force attacks.

Key words: micro-electrode-dot-array, biochip, logic encryption, intellectual property protection, outsourcing production

中图分类号:

TP309

刘灵清, 董晨, 刘西蒙, 等. MEDAguard：基于逻辑加密的微电极点阵生物芯片知识产权保护方案[J]. 电子学报, 2022, 50(2): 440-445.

Ling-qing LIU, Chen DONG, Xi-meng LIU, et al. MEDAguard: A Logic Encryption Scheme for Micro-Electrode-Dot-Array Biochips IP Protection[J]. Acta Electronica Sinica, 2022, 50(2): 440-445.

图/表 6

图1 微电极点阵生物芯片的架构

图2 微电极点阵生物芯片设计与制造流程

图3 微电极点阵生物芯片的使用流程

图4 MEDAguard中逻辑加密模块工作流程的示例，其中W为废液滴，I为生化协议中的某一液滴，液滴的移动轨迹如箭头所示

图5 插入逻辑加密模块的示例序列图

表1 暴力攻击仿真实验结果

生化协议	混合-分离	逻辑加密模块	$T i = 1 / 20$	$T i = 1 / 50$	$T i = 1 / 100$	$T i = 1 / 500$
		3	95.0%	98.5%	99.7%	100.0%
$b i o s s a y 1$	30	7	99.0%	98.2%	99.5%	100.0%
		10	99.9%	100.0%	100.0%	100.0%
		3	94.6%	97.2%	99.7%	99.8%
$b i o s s a y 2$	50	7	96.8%	98.3%	99.0%	100.0%
		10	99.0%	100.0%	99.8%	100.0%

表1 暴力攻击仿真实验结果

生化协议	混合-分离	逻辑加密模块	$T i = 1 / 20$	$T i = 1 / 50$	$T i = 1 / 100$	$T i = 1 / 500$
		3	95.0%	98.5%	99.7%	100.0%
$b i o s s a y 1$	30	7	99.0%	98.2%	99.5%	100.0%
		10	99.9%	100.0%	100.0%	100.0%
		3	94.6%	97.2%	99.7%	99.8%
$b i o s s a y 2$	50	7	96.8%	98.3%	99.0%	100.0%
		10	99.0%	100.0%	99.8%	100.0%

参考文献 11

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MEDAguard：基于逻辑加密的微电极点阵生物芯片知识产权保护方案

MEDAguard: A Logic Encryption Scheme for Micro-Electrode-Dot-Array Biochips IP Protection

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