超声多角度平面波相干复合血流速度检测的参数研究

doi:10.12263/DZXB.20210235

电子学报 ›› 2022, Vol. 50 ›› Issue (10): 2478-2488.DOI: 10.12263/DZXB.20210235

超声多角度平面波相干复合血流速度检测的参数研究

何冰冰¹^,³, 张榆锋¹, 李支尧², 熊丽¹, 郎恂¹, 梁虹¹

^1.云南大学信息学院电子工程系，云南昆明 650091
^2.昆明医科大学第三附属医院超声科，云南昆明 650118
^3.云南贝泰妮生物科技集团股份有限公司，云南昆明 650090

收稿日期:2021-02-08 修回日期:2022-02-24 出版日期:2022-10-25
- 作者简介:
- 何冰冰女，1993年出生，内蒙古兴安盟人.中国生物医学工程学会会员.2021年在云南大学获工学博士学位.现为云南大学信息学院电子工程系讲师，云南贝泰妮生物科技集团股份有限公司博士后.主要研究方向为医学超声工程、超快超声血流成像、光电医美技术研发等.E-mail: hebingbing@ynu.edu.cn
  张榆锋（通讯作者）男，1965年出生，云南大理人.教授，博士生导师，中国电子学会高级会员，IEEE会员.1998—2001年在美国乔治华盛顿大学生物医学工程实验室任高级研究员，2008年在云南大学获工学博士学位.主要研究方向为数字信号处理、微弱信号检测、医学超声工程、光电医美技术研发等.
- 基金资助:
- 云南省基础研究专项重点项目 (202101AS070031); 云南省高校高原医学电子信息智能检测处理重点实验室项目 (CY21624108); 国家自然科学基金 (62003298)

Study on the Parameter Configuration of the Multi-Angle Ultrasound Plane Wave Compounding for the Blood Flow Velocity Measurement

HE Bing-bing¹^,³, ZHANG Yu-feng¹, LI Zhi-yao², XIONG Li¹, LANG Xun¹, LIANG Hong¹

^1.Department of Electronic Engineering，School of Information，Yunnan University，Kunming，Yunnan 650091，China
^2.Department of Ultrasound，The Third Affiliated Hospital of Kunming Medical College，Kunming，Yunnan 650118，China
^3.Yunnan Botanee Bio-technology Group Co. LTD. ，Kunming，Yunnan 650090，China

Received:2021-02-08 Revised:2022-02-24 Online:2022-10-25 Published:2022-10-11

摘要/Abstract

摘要：

本文研究了超声多角度平面波（Multi-angle Plane Wave，MPW）相干复合血流速度剖面（Blood Flow Velocity Profile，BFVP）检测的关键参数.基于Field II超声仿真平台开展仿真实验，分别建立水平、倾斜颈总动脉（Common Carotid Artery，CCA）平面波超声仿真模型.使用3~11个角度、间隔0.25°~16°的MPW扫描水平CCA生成复合图像，基于散斑跟踪法（Speckle Tracking，ST）测量BFVP；使用3个角度、间隔0.25°~20°的MPW扫描倾斜CCA生成复合回波信号，基于多普勒测速法（Doppler Velocimetry，DV）估计BFVP.对比预设理论速度剖面，ST法与DV法的最优参数分别为11个间隔1.0°、3个间隔3.0°的平面波.基于造影增强的兔髂动脉开展体内实验，验证了最优参数的有效性.综上所述，本文研究为MPW相干复合检测BFVP的参数设置提供参考，有助于获得准确的临床诊断信息.

关键词: 颈动脉, 超声, 血流速度剖面, 相干平面波复合, 最优参数

Abstract:

Key parameters of the ultrasonic multi-angle plane wave(MPW) coherent compounding for the blood flow velocity profile(BFVP) detection are studied. Based on the ultrasonic simulator Field II, ultrasound plane-wave simulation models of the horizontal and inclined common carotid arteries(CCAs) are built. MPWs with the number of angles from 3 to 11 and the interval of angles from 0.25° to 16° are used to scan the horizontal CCA model to generate the compounded images, and the BFVPs are measured with the speckle tracking(ST) method. Three-angle plane waves with the interval from 0.25° to 20° are used to scan the inclined CCA model to acquire the compounded echo signals, and the BFVPs are measured with the Doppler velocimetry(DV). Compared with preset theoretical velocity profiles, the optimum parameters for the ST and DV methods are 11 plane waves with an interval of 1.0°, and 3 plane waves with an interval of 3.0°, respectively. Based on the enhanced rabbit iliac arteries with the contrast agents, the in-vivo experiments are implemented to demonstrate the effectiveness of the optimum parameters. In summary, this work provides a reference for the parameter configuration on the MPW coherent compounding for the BFVP detection, which is helpful to obtain the accurate diagnosis information in clinics.

Key words: carotid artery, ultrasound, blood flow velocity profile, coherent plane-wave compounding, optimum parameter configuration

中图分类号:

TP391.9

何冰冰, 张榆锋, 李支尧, 等. 超声多角度平面波相干复合血流速度检测的参数研究[J]. 电子学报, 2022, 50(10): 2478-2488.

Bing-bing HE, Yu-feng ZHANG, Zhi-yao LI, et al. Study on the Parameter Configuration of the Multi-Angle Ultrasound Plane Wave Compounding for the Blood Flow Velocity Measurement[J]. Acta Electronica Sinica, 2022, 50(10): 2478-2488.

图/表 15

图1 倾斜角为β的平面波（a）依次激活阵元发射平面波（b）信号传输时间

图2 MPW相干复合原理图

图3 超声ST法原理图

图4 超声DV法原理图

图5 仿真CCA模型（a）水平CCA （b）倾斜CCA

表1 实验参数

参数类型	参数名称	参数值
声学参数	中心频率	5 MHz
	采样频率	100 MHz(仿真)
	采样频率	40 MHz(在体)
	声速	1540 m/s
	波长	$3.08 × 10 - 4$ m
	脉冲重复频率	20 kHz
	激励信号周期	2
超声换能器参数	换能器类型	线阵
	物理阵元数	128
	激活阵元数	128
	阵元宽度	$2.79 × 10 - 4$ m
	阵元间距	$2.5 × 10 - 5$ m
	阵元高度	0.005 m

表1 实验参数

参数类型	参数名称	参数值
声学参数	中心频率	5 MHz
	采样频率	100 MHz(仿真)
	采样频率	40 MHz(在体)
	声速	1540 m/s
	波长	$3.08 × 10 - 4$ m
	脉冲重复频率	20 kHz
	激励信号周期	2
超声换能器参数	换能器类型	线阵
	物理阵元数	128
	激活阵元数	128
	阵元宽度	$2.79 × 10 - 4$ m
	阵元间距	$2.5 × 10 - 5$ m
	阵元高度	0.005 m

图6 血管长轴切面的ST法测速结果（a）角度个数为3 （b）角度个数为5 （c）角度个数为7 （d）角度个数为9 （e）角度个数为11注：（a）~（c）的角度间隔均为1°.

图7 不同角度个数与间隔下的BFVP测量结果（a）角度个数为3 （b）角度个数为5 （c）角度个数为7 （d）角度个数为9 （e）角度个数为11

图8 30组水平颈动脉仿真实验ST法NRMSE的均值与标准差

图9 基于ST法的兔髂动脉实验结果

图10 基于ST法的BFVP抛物线拟合的决定系数R2的均值与标准差

图11 血管长轴切面的DV法测速结果（a）角度间隔为0.5° （b）角度间隔为10° （c）角度间隔为20° （d）不同角度间隔下的BFVP测量结果

图12 30组倾斜颈动脉仿真实验DV法NRMSE的均值与标准差

图13 基于DV法的兔髂动脉实验结果

图14 基于DV法的BFVP抛物线拟合的决定系数R2的均值与标准差

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超声多角度平面波相干复合血流速度检测的参数研究

Study on the Parameter Configuration of the Multi-Angle Ultrasound Plane Wave Compounding for the Blood Flow Velocity Measurement

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